Cuelure and methyl eugenol were included as commercially available. Kinetics data in rats are consistent with a rapid clearance from the blood, metabolism in the liver mediated by the p450 system, and excretion in the urine. Methyl eugenol is found in a number of plants over 450 species from 80 families including both. Rose bulgarian low methyl eugenol oil robertet groupe.
Following administration of a single oral dose of methyleugenol. It is rapidly absorbed following oral administration to rats and mice. Health questions and answers for static spinosad me. Methyl eugenol is present in the essential oils of several plant species. Ft methyl eugenol is the male attractant for many species of bactrocera fruit fly including the oriental fruit fly and the carambola fruit fly.
The substance identifiers displayed in the infocard are the best available substance name, ec number, cas number andor the molecular and structural formulas. Since methyl eugenol and ddvp were found in citrus fruit samples collected from homeowners trees, a more comprehensive monitoring program will be. Methyl eugenol 93152 100 eugenol methyl ether 4allyl1,2dimethoxybenzene solid polymeric matrix na na na section 4. The substance identity section is calculated from substance identification information from all echa databases. If the assumption is made that it is roughly 2025 drops to a millilitre.
Material safety data sheet sect ion 1 methyl eugenol 1 chemical product and company identification msds name. Abstract methyl eugenol me and inclusion of protein into the adult diet increase the mating competitiveness of the oriental fruit fly, bactrocera. Department of transportation hazard labels, and a general description of the chemical. The cotton was soaked with methyl eugenol, and the trapping period was january 1830, 1993. Column type active phase temperature c i reference comment.
Thescentry methyl eugenol cone isasemiochemical insectattractant forcontrol oftheoriental fruitfly bactrocera dorsalis. The propylene oxide in a threecomponent reaction with veratrol and ethyl cycnoacetate provided the reaction products in a low yield. In addition, methyl eugenol caused gene mutation in the liver of transgenic animals and induced mutation of. Benzene, 1,2dimethoxy4 2 propenyl, also known as methyl eugenol, is a chemical that occurs naturally in a variety of plants, including various herbs. In a subset of serum samples from adults participating in the third national health and nutrition examination. Although inaccurate, it is commonplace to measure essential oils in drops. Methyl eugenol is not an eye or skin irritant, and does not cause skinsensitization reactions such as allergic contact dermatitis in test animals. Pandey many of the bactrocera fruit fl y males are attracted either to methyl eugenol or to cuelure. Pdf different methods of methyl eugenol application enhance the. Biopesticides fact sheet for methyl eugenol me author. Process steam distillation using high performance fractionating columns. Tea tree oil distilled from melaleuca alternifolia has widespread use in the cosmetic industry as an antimicrobial as well as for other functions in topical products.
Association fema references safety assessment of allylalkoxybenzene derivatives used as flavoring substaces methyl eugenol and estragole. Biopesticides fact sheet for methyl eugenol me keywords. The role of me in citronella grass, cymbopogon nardus poaceae, in the strong attraction of dacus currently bactrocera fruit flies which also visited other plant species including flowers of papaya and colocasia antiquorum, was first discovered almost a century ago howlett 1915. With the new approach of combining the qra2, phototoxicity see item 2.
Detecting traces of methyl eugenol in essential oils. It is one of the main components found in the essential oil extracted from acorus calamus, bark of croton malambo and rhizomes of zingiber zerumbet, hedychium coronarium and etlingera cevuga. Depending on the quantity used, different samples may or may not breach the ifra restriction. Methyl isoeugenol isomethyleugenol is a phenylpropanoid, the methyl ether of isoeugenol. Methyl isoeugenol isomethyleugenol is a phenylpropanoid, the methyl ether of isoeugenol, found in certain essential oils. It is found in various essential oils methyl eugenol is found in a number of plants over 450 species from 80 families including both angiosperm and gymnosperm families and has a role in. Methyl eugenol, however, poses no risks that require mitigation. Firstaid measures if breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing.
Pdf detecting traces of methyl eugenol in essential oils. The comment period is intended to provide an opportunity for public input and a mechanism for initiating any necessary amendments to the. Methyl eugenol is the aromatic compound that conforms to the formula. Owing to its availability and strong attractant properties, it has been used both as a trapping agent in capturing native male fruit flies for population estimation, and as pest control. Tea tree oil, a case study article pdf available in flavour and fragrance journal 265. If the assumption is made that it is roughly 2025 drops to a millilitre, then each drop would constitute approximately 33 mg. Methyl eugenol can be found naturally in many kinds of spices such as clove oil, nutmeg, etc.
Methyl eugenol was genotoxic in a range of in vivo and in vitro assays, although it was not mutagenic in bacterial cells. Blended within a base oil, if the entire quantity were to be used in a massage, then just one drop of an essential oil containing 0. Attractiveness of methyl eugenolbaited traps to oriental. By exposing sterile males to the lure prior to release, it may be possible to combine programs of male annihilation and sterile insect release. Screening assessment for the challenge benzene, 1,2dimethoxy. A manual collection of syt, esyt, rph3a, rph3al, doc2, and. Attraction of nontarget species to fruit fly diptera. It is a colorless to pale yellow, aromatic oily liquid extracted from certain essential oils especially from clove oil, nutmeg, cinnamon, basil and bay leaf. The main route of exposure to spinosad is by touching the bait station. Of the four invasive pest fruit fl ies established in hawaii, oriental fruit fl y males are attracted to methyl eugenol whereas the melon fl y males are attracted to cuelure.
Some samples of rose oil contain no methyl eugenol whilst the content in bay can be as low as 0. Tephritidae are strongly attracted to methyl eugenol me 1,2dimethoxy42propenylbenzene. A wide variety of methyl eugenol price options are available to you, such as industrial flavor. Eugenol and methyl eugenol chemotypes of essential oil of species ocimum gratissimum l. Easytohandle fruit fly lure plugs university of hawaii.
Jan 11, 2017 tea tree oil distilled from melaleuca alternifolia has widespread use in the cosmetic industry as an antimicrobial as well as for other functions in topical products. For example, dibrom contains naled as an active ingredient in combination with methyl eugenol is commonly used in traps for both monitoring and eradication of the fruit fly population. Methyl eugenol is a naturally occurring flavour and fragrance found in a variety of different food sources, including spices, herbs and fruit and also as a component of natural essential oils. Department of agriculture, in accordance with the following directions and specifications. Health questions and answers for static spinosad me tm from inhaling the released vapor is negligible.
Methyl eugenol is a synthetic insect lure which has been used for the following. Methyl eugenol bound to liver dna and formed dna adducts in vi vo and in vitro. Many reports have shown that methyl eugenol is not among the major compounds of clove oil, its presence in clove oil is very small or even only in trace amounts eugenol, eugenol. The agency therefore is issuing the methyl eugenol tred, its risk assessments, and related support documents simultaneously for public comment. The agency has evaluated the potential risks associated with methyl eugenol and has determined, that there is a reasonable certainty that no harm to any population subgroup will result from dietary and water exposure to methyl eugenol from uses specified in the existing exemption for the requirement for tolerance for methyl eugenol under 40 cfr.
California epa california environmental protection agency. Methyl eugenol 1 is a highly potent attractant for the male fruit flies of several species, occurring widely as a natural product in the plant kingdom. It is the methyl ether of eugenol and is important to insect behavior and pollination. Methyl eugenol is produced by the methylation of eugenol 8. Parchem is open and ready to supply materials 18002823982 read more. Methyl eugenol, a fruitfly attractant, from the browning. Methyl eugenol is used as a fragrance in perfumes 0. Eight replicates of each of four treatments 0, 2, 10 and 20 drops of methyl eugenol were used to test dosage response. Methyl eugenol is used in commercial products as a flavorant at concentrations of 5 to 52 ppm and in fragrances at concentrations of 0. Methyl eugenol is an important part of the fruit fly control programs in states such as hawaii, florida, and california.
Safe drinking water and toxic enforcement act of 1986. Methyleugenol some chemicals present in industrial and. Eugenol and its methyl ether in the synthesis of 3methyl. Notification of the 49th amendment to the ifra code of practice. Methyl eugenol is a component of several essential oils that are sold for use in aromatherapy, massage oils and alternative medicines 7. Many reports have shown that methyl eugenol is not among the major compounds of clove oil, its presence in clove oil is very small or even only in trace amounts sigmaaldrich offers a number of methyl eugenol products. Synthesis of methyl eugenol from crude cloves leaf oil using.
Chemical listed effective november 16, 2001 as known to the state of california to cause cancer. It has a role as an allergen, a plant metabolite, a human blood serum metabolite and a sensitiser. The chemicals from the brown part of the leaves of proiphys amboinensis consist of a mixture of methyl eugenol, 5allyl1,2,3trimethoxybenzene, 3,4,5trimethoxyacetophenone, aliphatic hydrocarbons and longchain carboxylic acids. For breathing difficulties, oxygen may be necessary. Gcms method validation and levels of methyl eugenol in a. It is a phenylpropanoid, a monomethoxybenzene and a member of phenols. It is most effectively used in control release dispensers such as the ft mee wafer. Synthesis of methyl eugenol from crude cloves leaf oil. The environmental monitoring of methyl eugenol, naled and. Its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination.
Methyl eugenol is a phenylpropene a type of phenylpropanoid compound the methyl ether of eugenol. Sigmaaldrich offers a number of methyl eugenol products. Concerns were first raised by the european commissions scientific committee on consumer products in 2004 about the level of the potentially carcinogenic phenylpropanoid compound methyl eugenol in tea tree oil. Male fruit flies of the bactrocera dorsalis complex b. The chemical identifier fields include common identification numbers, the nfpa diamond u. Methyleugenol anthraquinone, azt, bromate ion and its water soluble salts, bromoethane, diuron, fumonisn b1, isoxaflutole, methyl eugenol, gemfibrozil, and zileuton under consideration for listing. The isoeugenol in a linear synthesis also gives a low yield of the target compounds.
The insect attractant methyl eugenol and the insecticide malathion are exempt from the requirement of tolerances on all raw agricultural commodities when used in combination in oriental fruit fly eradication programs under the authority of the u. The required eugenol based monomers were prepared through the hydration of the double bond of methyl eugenol, achieved in 60% yield by reaction with formic acid, followed by hydrolysis of the resulting formate 223 and conversion of the secondary alcohol 224 with triphosgene to afford 86% of the reactive chloroformate 225. Methyl eugenol allylveratrol is a natural chemical compound classified as a phenylpropene, a type of phenylpropanoid. I find isoeugenol to be a bit more floral and softer, and with a faint ham or salami undertone. Methyl eugenol effects on bactrocera dorsalis male total body.
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